发明名称 Method and apparatus for manipulation of cells and cell-like structures focused electric fields in microfludic systems and use thereof
摘要 An apparatus and method are disclosed for electromanipulation of at least one cell or cell-like structure having cell-like membranes, the method comprising the steps: (a) at least one cell or cell-like structure is transported from one or more sample containers located on a chip through microchannel(s) located on said chip into a chamber located on said chip, wherein said chamber contains electrode(s) connected to a voltage generator, wherein said microchannel provides a fluid contact between the sample containers, (b) said cell or cell-like structure(s) is placed close to said at least one electrode, and (c) an electrical field is applied and focused on said cell or cell-like structure(s), said electrical field being of a strength sufficient to obtain pore-formation or fusion of said at least one cell or cell-like structure with another cell or cell-like structure(s) present in said chamber.
申请公布号 US7018819(B2) 申请公布日期 2006.03.28
申请号 US20010996559 申请日期 2001.11.30
申请人 CELLECTRICON AB 发明人 ORWAR OWE;KARLSSON MATTIAS;CHIU DANIEL;STROMBERG ANETTE;KARLSSON ANDERS
分类号 C12N13/00;A61K9/127;C12N15/02;C12N15/87 主分类号 C12N13/00
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