发明名称 |
COMPOSITIONS AND METHODS FOR MODULATING RANK ACTIVITIES |
摘要 |
<p>The present invention provides methods for identifying agents capable of modulating RANK-mediated signaling pathways. The present invention also provides compositions and methods of using the same to treat osteoporosis or other RANK-related diseases. The present invention is based on the functional and structural analysis of three TRAF-binding motifs (PTM) - namely, PTM3, PTM5, and PTM6, each of which has been found to play a distinct role in the activation of RANK-mediated intracellular signaling. These PTMs can be used to screen for RANK modulators. These PTMs also represent potential drug targets for diseases that are associated with abnormal RANK expression or activity.</p> |
申请公布号 |
WO2006031718(A2) |
申请公布日期 |
2006.03.23 |
申请号 |
WO2005US32396 |
申请日期 |
2005.09.14 |
申请人 |
THE UAB RESEARCH FOUNDATION;FENG, XU;LIU, WEI;XU, DUORONG |
发明人 |
FENG, XU;LIU, WEI;XU, DUORONG |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|