发明名称 |
DIAGNOSTIC AND THERAPEUTIC USE OF KCNJ6 FOR ALZHEIMER'S DISEASE |
摘要 |
The present invention discloses a dysregulation of the KCNJ6 gene and the protein products thereof in Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing and prognosticating Alzheimer's disease in a subject, and for determining whether a subject is at increased risk of developing Alzheimer's disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating and preventing Alzheimer's disease and related neurodegenerative disorders using the KCNJ6 gene and its corresponding gene products. Screening methods for modulating agents of neurodegenerative diseases are also disclosed. |
申请公布号 |
WO2005108999(A3) |
申请公布日期 |
2006.03.23 |
申请号 |
WO2005EP52084 |
申请日期 |
2005.05.09 |
申请人 |
EVOTEC NEUROSCIENCES GMBH;VON DER KAMMER, HEINZ;POHLNER, JOHANNES |
发明人 |
VON DER KAMMER, HEINZ;POHLNER, JOHANNES |
分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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