发明名称 METHOD OF STABILIZATION OF PHYSIOLOGICALLY ACTIVE SUBSTANCE PRODUCED BY GENE RECOMBINANT
摘要 PURPOSE:In carrying out operations such as preservation, separation and purification, and lyophilization, to prevent reduction in activity, by adding albumin or gelatin to a physiologically active substance produced by a gene recombinant. CONSTITUTION:>=1mug, preferably >=100mug based on 1ml of solution containing a physiologically active substance of albumin and/or gelatin is added to the physiologically active substance that is produced by a gene recombinant, having cell disorder activities against L-M cell, and properties to cause hemorrhagic necrosis reaction at a tumor site when it is administered to BALB/c mouse to which Meth A sarcoma cancerous cell is transplanted. When powder having the physiologically active substance is used, an amount of the substance used is an amount to give the above-mentioned concentration when the powder is dissolved. Preferably the solution blended with albumin is preserved in the solution state directly at 0-10 deg.C, or in a lyophilized state at <=-20 deg.C.
申请公布号 JPS60260522(A) 申请公布日期 1985.12.23
申请号 JP19840115496 申请日期 1984.06.07
申请人 ASAHI KASEI KOGYO KK 发明人 SAKAMOTO HAJIME;KIYOTA TAKAO;ITOU HIRATAKA;HAYASHI HIROSHI
分类号 C12N15/09;A61K35/12;A61K35/14;A61K35/16;A61K38/00;A61K38/16;C07K14/00;C07K14/52;C07K14/525;C12N15/28 主分类号 C12N15/09
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