发明名称 |
Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex |
摘要 |
A particle including a matrix-forming agent and a polyelectrolyte-amphiphilic agent adduct wherein the polyelectrolyte-amphiphilic agent adduct is in physical communication with the matrix-forming agent. The particle further includes a coated magnetic field-responsive agent and a biomaterial. Methods of making the particle are provided. Also provided are methods of delivery of the biomaterial to a target cell or a target tissue including administering the particle having the matrix-forming agent, polyelectrolyte-amphiphilic agent adduct, the coated magnetic field-responsive agent and the biomaterial; providing a magnetic device associated with the target cell or the target tissue; applying a magnetic force to the particle; and guiding the particle toward the magnetic device by the magnetic force.
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申请公布号 |
US2006057211(A1) |
申请公布日期 |
2006.03.16 |
申请号 |
US20050250948 |
申请日期 |
2005.10.14 |
申请人 |
CHORNY MICHAEL;POLYAK BORIS;FISHBEIN ILIA;ALFERIEV IVAN;LEVY ROBERT J |
发明人 |
CHORNY MICHAEL;POLYAK BORIS;FISHBEIN ILIA;ALFERIEV IVAN;LEVY ROBERT J. |
分类号 |
A61K9/14;A61F2/06 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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