发明名称 |
Methods to reprogram splice site selection in pre-messenger rnas |
摘要 |
The present invention relates to a method of modulating splice site selection, splicing and alternative, the method comprising the step of hybridizing an oligonucleotide-protein conjugate to a target pre-mRNA molecule in a cell or cell extract, wherein the oligonucleotide-protein conjugate comprises an oligonucleotide moiety which comprises at least two distinct sequence elements: (i) a nucleic acid sequence that is complementary to a specific region upstream of the splice site in the target pre-mRNA molecule; and (ii) an extension containing a protein binding site sequence element for covalently binding a protein; wherein the protein moiety comprises a protein capable of modulating splicing of the splice site upon binding with the protein binding site.
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申请公布号 |
US2006058253(A1) |
申请公布日期 |
2006.03.16 |
申请号 |
US20050524359 |
申请日期 |
2005.08.09 |
申请人 |
CHABOT BENOIT;VILLEMAIRE JONATHAN;ELELA SHERIF A;NASIM FAIZ-UL H |
发明人 |
CHABOT BENOIT;VILLEMAIRE JONATHAN;ELELA SHERIF A.;NASIM FAIZ-UL H. |
分类号 |
A61K48/00;C12N15/09;A61K38/00;A61K38/16;A61P7/04;A61P7/06;A61P21/02;A61P21/04;A61P25/28;A61P27/02;A61P31/18;A61P35/00;C07K14/08;C07K14/47;C12N15/113;C12Q1/02;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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