Methods for stimulating tlr irf3 pathways for inducing anti-microbial, anti-inflammatory and anticancer responses

摘要

The present invention provides methods for stimulating Toll-like receptors (TLR) to activate IRF (e.g., an IRF3) and signaling pathway, and thereby directing an antimicrobial activity. The present invention also provides methods for identifying agents that bind and/or stimulate TLR and mediate induction of an IRF3 pathway, thereby directing an antimicrobial activity. Additionally, the invention provides methods and agents for suppressing stimulation of TLR, thereby directing an anti-inflammatory response.