FLAVIVIRUS VARIANTS HAVING PHENOTYPIC VARIATION AND IMMUNOGENIC COMPOSITIONS THEREOF
摘要
The present invention concerns isolated attenuated flaviviruses, such as West Nile viruses, having modifications that provide phenotypic variation, particularly in comparison to a more virulent reference strains. The invention encompasses the isolated viruses and immunogenic compositions thereof, in addition to methods to produce and utilize same.
申请公布号
WO2006029300(A2)
申请公布日期
2006.03.16
申请号
WO2005US32120
申请日期
2005.09.09
申请人
RESEARCH DEVELOPMENT FOUNDATION;BARRETT, ALAN, D.T.;TESCH, ROBERT, B.;DAVIS, C. TODD;BEASLEY, DAVID, W.C.
发明人
BARRETT, ALAN, D.T.;TESCH, ROBERT, B.;DAVIS, C. TODD;BEASLEY, DAVID, W.C.