SYNTHESIS OF RADIOLABELED SUGAR METAL COMPLEXES

摘要

The invention provides a method for manufacturing or preparing neutral, low
molecular weight 99mTc-labeled and 186Re-labeled carbohydrate complexes with
an improved radiochemical yield from a simple functionalized sugar, such as
glucosamine. In particular the synthesis relies on single ligand transfer
(SLT) or double ligand transfer (DLT) reactions for converting a ferrocene
compound into a rhenium or technetium tricarbonyl complex. The ferrocene
compound may be linked to a sugar through various functional groups including,
for example, thio, amino and alcohol functionalities to provide a wide range
of radiolabeled sugar complexes that include both water soluble and relatively
water insoluble compounds.