Preventives remedies for bone and joint diseases

摘要

A compound or its salt that inhibits the activity of a protein having an amino acid sequence which is the same or substantially the same amino acid sequence represented by SEQ ID NO: 1, an antibody to the above protein, an antisense nucleotide having a base sequence which is complementary or substantially complementary to the base sequence of a DNA encoding the above protein or its peptide fragment, etc. are usable as prophylactic/therapeutic agents for bone and joint diseases.