发明名称 |
CEA binding agents and compositions to reverse CEA-mediated tumorigenic effects on human cancer cells, restore sensitivity to drug induced apoptosis and uses thereof |
摘要 |
The present invention relates to differentiation, apoptosis and tumorigenicity. The present invention more particularly relates to compositions comprising ligands which target CEA such that the adhesion, differentiation-Inhibitory and apoptosis-resistance activities (tumorigenic effects) of Ig superfamily member, CEA, can be reduced or blocked. More particularly, the present invention relates to CEA-binding agents comprising compositions which reverse the CEA-mediated tumorigenic effects and enable a lowering of the doses of a chemotherapeutic agent. In one embodiment the invention relates to methods of reducing, preventing or reversing CEA-mediated tumorigenic effects comprising a use of an amount of a CEA declustering agent comprising compositions that can reverse a CEA mediated tumorigenic effect. In one embodiment, the invention further relates to compositions comprising a CEA declustering agent for reversing CEA-mediated tumorigenic effects and restoring drug induced apoptosis to human cancer cells and uses thereof.
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申请公布号 |
US2006051352(A1) |
申请公布日期 |
2006.03.09 |
申请号 |
US20050097252 |
申请日期 |
2005.04.04 |
申请人 |
STANNERS CLIFFORD P;ILANTZIS CHRISTIAN;ORDONEZ-GARCIA COSME |
发明人 |
STANNERS CLIFFORD P.;ILANTZIS CHRISTIAN;ORDONEZ-GARCIA COSME |
分类号 |
A61K39/395;A61K38/08;A61K38/12;A61P35/00;C07K7/06;C07K16/30 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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