发明名称 |
INFLUENZA THERAPEUTIC |
摘要 |
The present invention provides methods and compositions for inhibiting influenza infection and/or replication based on the phenomenon of RNA interference (RNAi) well as systems for identifying effective siRNAs and shRNAs for inhibiting influenza virus and systems for studying influenza virus infective mechanisms. The invention also provides methods and compositions for inhibiting infection, pathogenicity and/or replication of other infectious agents, particularly those that infect cells that are directly accessible from outside the body, e.g., skin cells or mucosal cells. In addition, the invention provides compositions comprising an RNAi-inducing entity, e.g., an siRNA, shRNA, or RNAi-inducing vector targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for treatment of influenza. |
申请公布号 |
WO2004028471(A3) |
申请公布日期 |
2006.03.09 |
申请号 |
WO2003US30502 |
申请日期 |
2003.09.29 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;CHEN, JIANZHU;EISEN, HERMAN, N.;GE, QING |
发明人 |
CHEN, JIANZHU;EISEN, HERMAN, N.;GE, QING |
分类号 |
A61K38/00;A61K48/00;C12N15/11;C12N15/113 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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