LIGAND-DEPENDANT ACTIVATION OF NUR77 AND USES THEREOF
摘要
<p>The present invention provides a method for inducing ligand-dependant Nur77 activation in a cell by contacting the cell with an effective dose of an agonist of Nur77. Also provided is a method for treating a mammal having a disease affected by modulation of Nur77 activity as well as a method for inducing apoptosis in a cell. The Nur77 agonists are preferably diindolylmethanes, and more preferably, methlylene-substituted diindolylmethanes. A representative example of the Nur77 agonists is 1,1-bis (3'-indolyl)-1-(p-substituted phenyl) methane.</p>
申请公布号
WO2006023891(A2)
申请公布日期
2006.03.02
申请号
WO2005US29885
申请日期
2005.08.23
申请人
THE TEXAS A & M UNIVERSITY SYSTEM;SAFE, STEPHEN, H.;CHINTHARLAPALLI, SUDAHKAR