DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH ALPHA-1A ADRENERGIC RECEPTOR (ADRA1A)

摘要

The invention provides a human ADRA1A which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases, respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases, respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of ADRA1A as well as pharmaceutical compositions comprising such compounds.