发明名称 |
PHARMACOLOGICAL PROFILING OF DRUGS WITH CELL-BASED ASSAYS |
摘要 |
The instant invention provides a method for establishing safety profiles for chemical compounds, as well as pharmacological profiling said method comprising (A) testing the effects of said chemical compounds on the amount and/or post-translational modifications of two or more macromolecules in intact cells; (B) constructing a pharmacological profile based on the results of said tests; and (C) comparing said profile to the profile(s) of drugs with established safety characteristics. Additionally, the invention is also directed to a composition comprising an assay panel, said panel comprising at least one high-content assay for the amount and/or post-translational modification of a protein and at least one high-content assay for the amount and/or subcellular location of a protein-protein interaction. |
申请公布号 |
WO2006023576(A2) |
申请公布日期 |
2006.03.02 |
申请号 |
WO2005US29278 |
申请日期 |
2005.08.18 |
申请人 |
ODYSSEY THERA, INC. |
发明人 |
WESTWICK, JOHN, K.;YU, HELEN;MACDONALD, MARNIE, L. |
分类号 |
C12Q1/02;C12M1/34 |
主分类号 |
C12Q1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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