| 摘要 |
Density-matching is used to provide suspending vehicles, pharmaceutical suspensions, dosage forms, and kits as well as methods of making and using the vehicles, suspensions, and dosage forms. Pharmaceutical suspensions comprising a pharmaceutically active agent having an active agent density, rho<SUB>A</SUB>, and a suspending vehicle having a suspending vehicle density, rho<SUB>SV</SUB>; wherein the suspending vehicle density, rho<SUB>SV </SUB>is substantially equal to the active agent density, rho<SUB>A</SUB>, are provided. Suspending vehicles comprise at least one suspending agent. The suspending vehicles can further comprise at least one density-modifying solid in such a combination with the suspending agent as to create a suspending vehicle that has a density that substantially matches the density of a desired drug particle or combination of drug particles. Pharmaceutical suspensions that remain homogenous during prolonged storage can be obtained.
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