| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for preparing an acid addition salt of a quinazolinone compound with a higher purity by inhibiting production of an N-oxide form of quinazolinone. SOLUTION: In the method for preparing the acid addition salt of the quinazolinone compound of formula (1) (wherein ring A<SP>1</SP>is a benzene ring or the like; R<SP>1</SP>and R<SP>2</SP>are each a hydrogen atom or the like; X is an oxygen atom or the like; Y is an alkyl group or the like; and Z is a group of formula B (wherein W is a 1-6C alkylene group; and R<SP>3</SP>and R<SP>4</SP>are each a hydrogen atom or the like) or a group or formula C (wherein A<SP>2</SP>and R<SP>5</SP>are as mentioned above)), production of the N-oxide form of the quinazolinone of formula (2) (wherein ring A<SP>1</SP>, R<SP>1</SP>, R<SP>2</SP>, X and Y are as mentioned above; and Z' is a group of formula A (wherein W, R<SP>3</SP>and R<SP>4</SP>are as mentioned above) or the like) is inhibited by reacting the quinazolinone compound of formula (1) with an acid in an organic solvent in the presence of an antioxidant. COPYRIGHT: (C)2006,JPO&NCIPI
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