发明名称 |
Compositions and methods for detecting Treponema pallidum |
摘要 |
Methods for the specific and highly sensitive detection of Treponema pallidum infection comprising the use of specific antigenic proteins and peptides unique to Treponema pallidum are provided. In particular, detection assays based recognition of acidic repeat protein are provided. The methods of the present invention are useful for detection of primary syphilis at early stages of infection. In addition, the methods and compositions disclosed herein are directed to the differential detection of specific Treponema infections enabling the identification of causative agents for specific Treponema disease states: syphilis (Treponema pallidum subspecies pallidum), yaws (Treponema pallidum subspecies pertenue CDC-1 or CDC-2 strain), and bejel (Treponema pallidum subspecies endemicum).
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申请公布号 |
US7005270(B2) |
申请公布日期 |
2006.02.28 |
申请号 |
US20010017168 |
申请日期 |
2001.12.14 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
LIU HSI;STEINER BRET M.;RODES BERTA |
分类号 |
G01N33/571;A61K39/002;A61K39/02;C07K14/20;C07K16/12;C07K16/20;C12P21/08;C12Q1/00;C12Q1/68;G01N33/53;G01N33/554;G01N33/569 |
主分类号 |
G01N33/571 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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