发明名称 |
Detection of biopolymers utilizing photo-initiated charge separation |
摘要 |
A method for detecting the presence of target molecules bound to a working electrode in a first location. The first location is coated with a detection solution containing labeling molecules that include a first charge-separation moiety attached to a first molecule that binds to the target molecule. The first charge-separation moiety includes a material that generates hole-electron pairs in response to being illuminated by light in a first band of wavelengths. After removing any unbound labeling, the working electrode is immersed in a solution containing a compound that is oxidized by the generated holes. The first location is then selectively illuminated with light in the first band; and the change in the current and/or potential is measured between the working electrode and a reference electrode in contact with the solution. The first charge-separation moiety is preferably constructed from particles of a semiconducting material such as TiO<SUB>2</SUB>.
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申请公布号 |
US7005268(B2) |
申请公布日期 |
2006.02.28 |
申请号 |
US20020098091 |
申请日期 |
2002.03.13 |
申请人 |
AGILENT TECHNOLOGIES, INC. |
发明人 |
ROITMAN DANIEL B.;WARD CALVIN B.;INAOKA SEIJI |
分类号 |
G01N33/53;C12Q1/68;G01N33/543 |
主分类号 |
G01N33/53 |
代理机构 |
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地址 |
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