BRAIN CELL PROTECTIVE AGENT

摘要

The present invention relates to a novel brain cell protective agent having for its active ingredient a morphinan derivative represented with Compound 1 (see figure I) or pharmacologically acceptable acid addition salt thereof. The compounds used in the present invention were found to have excellent defensive effects against brain nerve cell necrosis in both in vitro and in vivo pharmacological evaluations, and can be used as useful preventive and therapeutic agents of ischemic brain disorders, brain nerve cell disorders and dementia.