Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases

摘要

Disclosed is the use of a derivative of pyrazoline with the general formula (I) wherein R1 represents an atom of hydrogen, a methyl, fluoromethyl, difluoromethyl, trifluoromethyl group, carboxylic acid, lower alkyl carboxylate with 1 to 4 carbon atoms, carboxamide or cyano group, R2 represents an atom of hydrogen or a methyl group, R3, R4, R7 and R8 like or different, represent an atom of hydrogen, chlorine, fluorine, a methyl, trifluoromethyl or methoxy group, R5 represents an atom of hydrogen, chlorine, fluorine, a methyl, trifluoromethyl, methoxy, trifluoromethoxy, methyl sulphonyl, aminosulphonyl or acetylaminosulphonyl group, R6 represents an atom of hydrogen, chlorine, fluorine, a methyl, trifluoromethyl, methoxy, trifluoromethoxy or methylsulphonyl group, with the condition that one of the substituents R5 or R6 is a methylsulphonyl, aminosulphonyl or acetylaminosulphonyl group, and with the condition that when R1 represents a methyl group R2 represents an atom of hydrogen or a methyl group, R3 and R8, like or different, represent an atom of hydrogen, chlorine, fluorine, a methyl or trifluoromethyl group, R4 represents an atom of hydrogen, fluorine, a methyl, trifluoromethyl or methoxy group, R5 represents a fluorine atom, a trifluoromethyl, trifluoromethoxy, methylsulphonyl, aminosulphonyl or acetylaminosulphonyl group, R6 represents an atom of hydrogen, chlorine, fluorine, a methyl, trifluoromethyl, methoxy, trifluoromethoxy or methylsulphonyl group, with the condition that one of the substituents R5 or R6 is a methylsulphonyl, aminosulphonyl or acetylaminosulphonyl group, and R represents an atom of hydrogen, chlorine, fluorine, a methyl, trifluoromethyl or methoxy group; Or one of their physiologically acceptable salts, in the preparation of a medicament for preventing or treating cell proliferation diseases in mammals, including man. Further disclosed is use of a compound with the general formula (I), or one of its physiologically acceptable salts in the preparation of a medicament for preventing or treating cell proliferation diseases in mammals, including man, wherein the medicament further comprises another product commonly used in the treatment of neoplasias, producing in this case a synergy.