摘要 |
Disclosed is a process for preparing a granulate that exhibits rapid and excellent water dispersibility and contains liposoluble and hydrophobic substances, having a water solubility at 20°C of less than 20 ug/mL, the process comprising: (i) the dispersion of substance (A) in water in the presence of a surfactant (B), (ii) the incorporation of a water soluble polyhydroxylated solid excipient (C) in the aqueous dispersion until a granulable pasty mass is obtained, and (iii) the granulation of the mass, wherein the surfactant (B) and the polyhydroxylated solid excipient (C) are present in amounts by weight of, respectively, from 0.013 to 0.7 of (B) and from 1 to 6 of (C), per unit of liposoluble substance (A). |