MULTIPHASE BIOCOMPATIBLE SEMI-PERMEABLE MEMBRANE FOR BIOSENSORS

摘要

This invention relates to a novel two phase biocompatible semi-permeable mem- brane for biosensors and more particularly to a homogenous membrane for us- age in in-vivo sensing of glucose by an enzyme. The membrane comprises of a continuous hydrophilic phase of water swellable polyurethane having discrete particles of polydimethyl siloxane dispersed therein. Furthermore, a membrane having good properties for use as the outer membrane in a biosensor continuous determination of the blood glucose level in vivo, can be prepared by spraying of a polymer solution in a big number of spraying steps, for example, more than 20 steps.