发明名称 |
REGULATION OF FOOD INTAKE AND GLUCOSE PRODUCTION BY MODULATION OF LONG-CHAIN FATTY ACYL-CoA LEVELS IN THE HYPOTHALAMUS |
摘要 |
Methods of reducing food intake and glucose production in a mammal, or restoring hepatic autoregulation are provided. The methods involve increasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus, or stimulating efferent fibers in the hepatic branch of the vagus nerve. Also provided are methods of increasing food intake and glucose production in a mammal. The methods involve decreasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus of the mammal. |
申请公布号 |
WO2004071458(A3) |
申请公布日期 |
2006.02.23 |
申请号 |
WO2004US04344 |
申请日期 |
2004.02.12 |
申请人 |
VERSITY ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNI;ROSSETTI, LUCIANO;OBICI, SILVANA |
发明人 |
ROSSETTI, LUCIANO;OBICI, SILVANA |
分类号 |
A61K;A61K6/00;A61K31/00;A61K31/7088;A61K31/7105;A61K38/43;A61K38/44;A61K38/45;A61K38/46;A61K39/395;A61K48/00;A61P31/12;A61P31/18;A61P35/00;C07K16/18;C12N9/10 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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