| 摘要 |
The invention relates to an improved process for the determination of the gamma-secretase activity, individual components of the process and the use of the process. The present invention relates to an improved process for the determination of the gamma-secretase activity and for the detection of gamma-secretase, a subunit protein of gamma- secretase, or a gammasecretase-like proteinase; particular embodiments of the process relate on the one hand to processes for the identification of a gamma-secretase or of a cDNA which codes for a gamma-secretase, a subunit protein of gamma-secretase, or a gamma-secretase-like proteinase, and on the other hand to processes for the identification of substances which can inhibit the activity of a gamma-secretase, a subunit protein of gamma-secretase, or a gamma-secretase-like proteinase. Such substances have particular importance, as they can be used, e.g., as pharmaceutical active compounds, e.g., for the treatment of Alzheimer's disease.
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