| 摘要 |
<p>DNA molecules, such as expression vectors, comprising a radiation-inducible IEX-1 promoter operably coupled to a sequence encoding a biologically-active protein or polypeptide are useful for gene transfer applications. Preferably, the promoter is an IEX-1 promoter that is modified to provide increased radiation response and or specificity. Methods for delivery of such a DNA expression vector to tissues of a host animal, and other methods of using such a molecule are described. The vectors and methods are useful for research purposes, for example, for the controlled modification and study of cellular response to radiation using in vitro and in vivo methods. The vectors and methods are also useful in, and relate to, therapeutic compositions and methods, for example in the treatment of cancers, such as prostate cancer.</p> |
