| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention concerns medicine drugs, particularly combination for pain mitigation, including synergic dosage of (S,S)-reboxetine or its pharmaceutically acceptable salt or solvate and 5 type phosphodiesterase inhibitor (PDEV), 3-ethyl-5-[5-(4-ethylpiperasine-1-ylsulfonyl)-2-n-propoxyphenyl]-2-(pyridin-2-yl)methyl-2,6-dihydro-7H-pyrasolo[4,3-d]pyrimidine-7-on. In addition, invention concerns composition and kit for pain mitigation, including the claimed compounds, and application of the combination or composition in pain mitigation. ^ EFFECT: synergic effect of composition. ^ 12 cl, 1 dwg, 1 ex |
