发明名称 |
Variants of traf2 which act as an inhibitor of tnf-alpha (tnfalpha) signaling pathway |
摘要 |
The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF alpha signaling path-way. In particular, applicants have isolated a splice variant of TRAF2 referred to hereinafter as "TRAF2 truncated" or "TRAF2TR" and a TRAF2 expression construct with enhanced dominant negative properties, hereafter referred to as "TRAF2 truncated-deleted" or "TRAF2TD". Both TRAF2TR and TRAF2TD have the ability to inhibit the TNF alpha signaling pathway and in TRAF2TD, this ability is greatly enhanced, greatly reducing the response to TNF alpha binding.
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申请公布号 |
US6998475(B1) |
申请公布日期 |
2006.02.14 |
申请号 |
US20020018030 |
申请日期 |
2002.09.23 |
申请人 |
CENTELION SAS |
发明人 |
SEARFOSS, III GEORGE H.;PAGNONI MARCO F.;IVASHCHENKO YURI D.;GUO KUN;CLARK KENNETH L. |
分类号 |
C12N5/10;C07K14/705;C12N15/12;C12N15/63 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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