| 摘要 |
PROBLEM TO BE SOLVED: To provide a new analgesic composition for external use for enhancing skin-permeating property of tramadol or its pharmaceutically acceptable salt and exhibiting excellent pharmacological effect. SOLUTION: The new medicinal composition for external use comprises tramadol or its pharmaceutically acceptable salt as an active ingredient and comprises one or more kinds of absorption promoters selected from menthol, O-ethylmenthol and limonene. Since the composition comprises tramadol having stronger analgesic effect than analgesic effect of nonsteroidal anti-inflammatory analgesic agent, having lower adverse effect frequency and scarcely causing resistance, physical dependence, abuse, etc., compared with a narcotic analgesic agent such as morphine as an active ingredient, the composition has high usability as an external preparation for analgesic which is excellent in effects, safe and useable for long period. COPYRIGHT: (C)2006,JPO&NCIPI
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