Acetaminophen as a Marker of Hepatic Disorders

摘要

The present invention provides methods for diagnosing human hepatic disorders, identifying a human subject at risk of an adverse drug reaction, and determining an appropriate dosage of a therapeutic drug for a human subject.

主权项

1. A method for diagnosing a hepatic disorder in a human, comprising
(a) determining an amount of acetaminophen (APAP)-glucuronide in a plasma sample and/or a urine sample obtained from a human subject after the human subject was administered acetaminophen (APAP), wherein the human subject is at risk of a hepatic disorder; (b) comparing the amount of APAP-glucuronide in one or both of the plasma sample and the urine sample to a control; and (c) identifying the human subject as having a hepatic disorder if the amount of APAP-glucuronide in one or both of the plasma sample and the urine sample is elevated relative to the control.