发明名称 OLANZAPINE SALTS AND THEIR CONVERSION TO OLANZAPINE FREE BASE
摘要 The present invention provides salts olanzapine useful as intermediates in the isolation of olanzapine from complex reaction mixtures. These salts can be used for the production of olanzapine base which has a suitable purity for pharmaceutical use and can easily be converted to anhydrous olanzapine polymorphic form I, in high yields.
申请公布号 WO2006010620(A2) 申请公布日期 2006.02.02
申请号 WO2005EP08218 申请日期 2005.07.28
申请人 KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO;SIMONIC, IGOR;LENARSIC, ROMAN;KOTAR-JORDAN, BERTA;ZUPET, ROK;GNIDOVEC, JOZE 发明人 SIMONIC, IGOR;LENARSIC, ROMAN;KOTAR-JORDAN, BERTA;ZUPET, ROK;GNIDOVEC, JOZE
分类号 C07D495/04;A61K31/5513;A61P25/18 主分类号 C07D495/04
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