An effective contrast agent for use in MRI-based methods for directly determining tissue oxygenation in a subject using MRI equipment as well as methods for assessing tissue oxygenation were discovered. Methods employ a blood substitute bound to a water soluble polymer as an MRI contrast agent. In the experiments described herein, polyethylene glycol (PEG) derivatives of bovine hemoglobin (pegylated Hb or PEG-Hb) were used as the contrast agent.
申请公布号
WO2005097208(A3)
申请公布日期
2006.01.26
申请号
WO2005US10112
申请日期
2005.03.25
申请人
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;ROSS, EDWARD, ALLAN;BATICH, CHRISTOPHER, DAVID