USE OF HMGB1 FOR WOUND HEALING

摘要

The present invention describes the role of HMGB1 in improving wound healing, in particular in a model of diabetes. Other evidences based on the effect of glycyrrhizin, the underexpression of HMGB1 in the skin and fibroblast of diabetic subjects, the accumulation of RAGE in the skin of diabetic mice and the chemoattractant properties of HMGB1 on normal and diabetic human cells demonstrate that HMGB1 can be advantageously utilized for preparing medicament specifically devoted to wound healing, in particular for diabetic subjects.