发明名称 |
POLYVALENT PROTEIN COMPLEX |
摘要 |
<p>The invention provides for a polyvalent protein complex (PPC) comprising two polypeptide chains generally arranged laterally to one another. Each polypeptide chain typically comprises 3 or 4 "v-regions", which comprise amino acid sequences capable of forming an antigen binding site when matched with a corresponding v-region on the opposite polypeptide chain. Up to about 6 "v-regions" can be used on each polypeptide chain. The v-regions of each polypeptide chain are connected linearly to one another and may be connected by interspersed linking regions. When arranged in the form of the PPC, the v-regions on each polypeptide chain form individual antigen binding sites.</p> |
申请公布号 |
EP1618181(A2) |
申请公布日期 |
2006.01.25 |
申请号 |
EP20040750590 |
申请日期 |
2004.04.22 |
申请人 |
IBC PHARMACEUTICALS;IMMUNOMEDICS, INC. |
发明人 |
ROSSI, EDMUND, A.;CHANG, CHIEN-HSING;MCBRIDE, WILLIAM, J. |
分类号 |
A61K39/00;A61K39/395;C07H21/04;C07K14/475;C07K14/52;C07K16/00;C07K16/30;C07K16/44;C07K16/46;C12N;C12N15/00;C12P21/04;C12Q1/68;(IPC1-7):C12N1/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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