发明名称 |
PROCESS FOR PREPARING THE ANTIVIRAL AGENT [1S-(1ALPHA,3ALPHA,4BETA)]-2-AMINO-1,9-DIHYDRO-9-[4-HYDROXY-3-(HYDROXYMETHYL)-2-METHYLENECYCLOPENTYL]-6H-PURIN-6-ONE |
摘要 |
The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising:
(a) adsorbing the diluted mixture onto a hydrophobic resin bed;
(b) washing the resin bed with water to remove salt; and
(c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent. |
申请公布号 |
PL377263(A1) |
申请公布日期 |
2006.01.23 |
申请号 |
PL20030377263 |
申请日期 |
2003.12.10 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
PENDRI YADAGIRI R.;CHEN CHUNG-PIN H.;PATEL SUNIL S.;EVANS JEFFREY M.;LIANG JING;KRONENTHAL DAVID R.;POWERS GERALD L.;PRASAD SIVA JOSYULA;BIEN JEFFREY T.;SHI ZHONGPING;PATEL RAMESH N.;CHAN YEUNG Y.;RIJHWANI SUSHIL K.;SINGH AMBARISH K.;WANG SHAOPENG;STOJANOVIC MILAN;POLNIASZEK RICHARD;LEWIS CHARLES;THOTTATHIL JOHN K.;KRISHNAMURTY DHILEEPKUMAR;ZHOU MAOTANG X.;VEMISHETTI PURUSHOTHAM;BANERJEE AMIT;KUCERA DAVID J. |
分类号 |
C07F7/08;C07D473/12;C07D473/18;C07F7/18 |
主分类号 |
C07F7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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