Preparation of arylamine, useful as intermediates in e.g. pesticides, comprises reacting arylhalogenide compounds with amino compounds in the presence of organic or inorganic base and catalyst (palladium and phosphine compounds)

摘要

Preparation of arylamine (I) comprises reacting arylhalogenide compounds (3-6) with amino compounds (7 or 8) in the presence of organic or inorganic base and a catalyst (a palladium compound and a phosphine compound). Preparation of arylamine (I) comprises reacting haloaryl compounds of formulae (3-6) with amino compounds of formula (7 or 8) in the presence of organic or inorganic base and a catalyst (a palladium compound and a phosphine compound of formula (1 or 2)). R10>-R24> = dialkylamino, alkyl-aryl-amino, diarylamino, 1-20C alkyl or 1-20C alkoxy or 3-20C cycloalkyl ring, phenyl, naphthyl or higher condensed system (such as anthracenyl, phenanthrenyl, pyrenyl or aralkyl such as or benzyl or (1-methyl-ethyl)phenyl, which are optionally substituted) or vinyl (all substituted with alkoxy, dialkylamino, aryloxy, aryl alkyl amino, aralkylamino, diarylamino), Cl, Br, I, H or CN; (A)m = alkylene (where m is 1-20), vinylene (where m is 1-6), arylene (where m is 1-6) (where the alkylene, vinylene and arylene are substituted with substituents of R10>-R24>) or N, O or S (where m is 0); R5>-R7> = 1-6C alkyl, 3-20C cycloalkyl, phenyl, naphthyl, aralkyl or higher condensed system (all optionally substituted); R1>-R4> = 1-6C alkyl, 3-20C cycloalkyl, phenyl, naphthyl or higher condensed system (all optionally substituted); and Z = 1-6C alkyl. The groups of R10>-R24> with the exception of univalent groups can form part of ring between different aryl rings with the proviso that Cl, Br or I is directly bounded to R10>-R24> of the ring 3-6. Provided that at least one of R5>-R7> is optionally substituted phenyl, naphthyl, higher condensed system, aralkyl or cycloalkyl. [Image] [Image] [Image] [Image].