| 发明名称 |
Liquid phase peptide synthesis of KL-4 pulmonary surfactant |
| 摘要 |
The invention realtes to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu<SUB>4</SUB>)<SUB>4</SUB>-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the alpha-carbon.
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| 申请公布号 |
US2006014929(A9) |
申请公布日期 |
2006.01.19 |
| 申请号 |
US20020156882 |
申请日期 |
2002.05.29 |
| 申请人 |
ABDEL-MAGID AHMED F;EGGMANN URS;MARYANOFF CYNTHIA A;THALER ADRIAN;VILLANI FRANK J |
发明人 |
ABDEL-MAGID AHMED F.;EGGMANN URS;MARYANOFF CYNTHIA A.;THALER ADRIAN;VILLANI FRANK J. |
| 分类号 |
C07K7/08;A61K38/00;C07K1/12;C07K5/083;C07K5/09;C07K14/785 |
主分类号 |
C07K7/08 |
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