| 摘要 |
A process is described for the stereoselective synthesis of a chiral lactone which can be used as an intermediate in the synthesis of biotin. The process includes a reaction sequence in which a cyclic meso- carboxylic acid anhydride is converted with the aid of a chiral alcohol with ring opening into a dicarboxylic acid monoester. With respect to the dicarboxylic acid monoester obtained from the cyclic meso-carboxylic acid anhydride and the chiral alcohol, the reaction proceeds diastereoselectively. The reaction is performed in the presence of a specific catalyst improving the diastereomeric purity of the dicarboxylic acid monoester.
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