发明名称 |
Combinant polypeptide for use in the manufacture of vaccines against Campylobacter induced diarrhea and to reduce colonization |
摘要 |
This invention comprises a recombinant protein comprising the maltose binding protein (MBP) of Escherichia coli fused to amino acids 5-337 of the FlaA flagellin of Campylobacter coli VC167 which has provided evidence of immunogenicity and protective efficacy against challenge by a heterologous strain of campylobacter, Campylobacter jejuni 81-176 in mammals. The invention further comprises a recombinant DNA construct encoding the immunodominant region (region I through III) of flagellin from Campylobacter spp. for use as a component of a vaccine against Campylobacter diarrhea. The invention therefore represents an effective treatment against Campylobacter but avoids inducing the autoimmune Guillain Barre Syndrome (GBS), a post-infection polyneuropathy caused by Campylobacter molecular mimicry of human gangliosides which has hampered the development of vaccines heretofore.
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申请公布号 |
US6987176(B1) |
申请公布日期 |
2006.01.17 |
申请号 |
US19990439311 |
申请日期 |
1999.11.12 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY |
发明人 |
GUERRY PATRICIA;LEE LANFONG H.;BURG EDWARD;TRUST TREVOR J. |
分类号 |
C07H21/02;A61K39/00;A61P25/02;A61P31/04;A61P37/02;C07K14/205;C07K14/245 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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