| 摘要 |
PROBLEM TO BE SOLVED: To provide an industrially advantageous method for producing an optically active N-substituted pyrrolidine-3-carboxylic acid in a few reaction steps. SOLUTION: The method for producing the optically active N-substituted pyrrolidine-3-carboxylic acid of the general formula (2) comprises hydrolyzing the corresponding N-substituted pyrrolidine-3-carboxylic ester of the general formula (1) in the presence of an enzyme having the ability to asymmetrically hydrolyze the above ester. In the formulas (1) and (2), P is an imino group-protecting group; R is a 1-8C straight-chain alkyl or 1-8C branched alkyl; and * denotes an asymmetric carbon atom. COPYRIGHT: (C)2006,JPO&NCIPI
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