| 发明名称 |
LIVE ATTENUATED NIDOVIRUS VACCINES |
| 摘要 |
The present invention is directed live, attenuated Nidovirus vaccines, and in a particular embodiment, to coronavirus vaccines. The vaccine comprises a viral genome encoding a replicase polypprotein having at least one proteinase cleavage site that exhibits reduced or no cleavage. Such viruses show reduced |
| 申请公布号 |
WO2005009335(A3) |
申请公布日期 |
2006.01.12 |
| 申请号 |
WO2004US12441 |
申请日期 |
2004.04.22 |
| 申请人 |
VANDERBILT UNIVERSITY;DENISON, MARK |
发明人 |
DENISON, MARK |
| 分类号 |
A61K;A61K39/215;C07K14/165;C12N15/50 |
主分类号 |
A61K |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
