METHOD FOR PRODUCING OPTICALLY ACTIVE THREO-beta-ALKYLTRYPTOPHAN DERIVATIVE AND ITS INTERMEDIATE

摘要

PROBLEM TO BE SOLVED: To provide a method for producing an optically active threo-β-alkyltryptophan derivative by which it can industrially suitably be mass-produced. SOLUTION: This method for producing the optically active compound expressed by formula (I) [wherein, R1, R2are the same or different and are each a lower alkyl which may be substituted; R3is H, a lower alkyl which may be substituted, an acyl, carboxy which may be esterified or amidated, sulfonyl which may be esterified or amidated or silyl which may be substituted; and R4, R5are the same or different and are each H or a lower alkyl which may be substituted] or its salt is characterized by performing the reaction of a mixture of 2 kinds of optically active compounds or their salts with an optically active compound expressed by formula (II) [wherein, R6is an acyl]. COPYRIGHT: (C)2006,JPO&NCIPI