COMPOSITIONS AND METHODS RELATING TO PYRIMIDINE SYNTHESIS INHIBITORS

摘要

Provided herein are compositions comprising a pyrimidine synthesis inhibitor and a pharmaceutically acceptable carrier. Such compositions can be used in methods of increasing Na<SUP>+</SUP> dependent fluid clearance by a pulmonary epithelial cell; of treating a pulmonary disease in a subject; of reducing one or more symptoms or physical signs of a respiratory syncytial virus infection in a subject; of identifying a subject at risk for respiratory syncytial virus infection and administering to the subject a composition comprising an effective amount of a pyrimidine synthesis inhibitor; of identifying a subject with a respiratory syncytial virus infection and administering to the subject a composition comprising a pyrimidine synthesis inhibitor in an amount effective to reduce Na<SUP>+</SUP> dependent alveolar fluid in the subject; and of screening for a test compound that increases Na<SUP>+</SUP> dependent fluid uptake by a pulmonary epithelial cell.