BENZO(C)QUINOLIZINE DERIVATIVES AND THEIR USE AS 5 ALPHA-REDUCTASES INHIBITORS

摘要

The present invention refers to benzoÄcÜquinolizines derivatives, fully and partially saturated, having formula (I) and their pharmaceutically acceptable salts which proves useful for pharmaceutical and agricultural use being capable of inhibiting the 5 alpha -reductase enzyme either selectively in respect of 5 alpha R-I and 5 alpha R-II or on both the iso-enzymes. Compounds (1) can be used to regulate growth and act as herbicides, or to treat acne, baldness, prostatic cancer and prostatic hypertrophy.