发明名称 QUINOLINE DERIVATIVES
摘要 The invention relates to compounds of general formula (I) wherein R is selected from ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec.-butyl and allyl; R4 is selected from hydrogen and pharmaceutically acceptable inorganic and organic cations; R5 is selected from methyl, ethyl, n-propyl, iso-propyl, methoxy, ethoxy, chloro, bromo, CF3, and OCHxFy; wherein x = 0 - 2, y = 1 - 3 with the proviso that x + y = 3; R6 is hydrogen; or R5 and R6 taken together are methylenedioxy; and any tautomer thereof. The invention also relates to pharmaceutical compositions containing a compound of general formula (I) together with a pharmaceutically acceptable carrier. Included are also processes for the preparation of the compounds of formula (I), as well as methods of treating mammals suffering from diseases resulting from autommunity and pathological inflammation by administrering a compound having formula (I) to said mammal.
申请公布号 PL190441(B1) 申请公布日期 2005.12.30
申请号 PL19990343420 申请日期 1999.04.26
申请人 ACTIVE BIOTECH AB 发明人 BJOERK ANDERS;JOENSSON STIG;FEX TOMAS;HEDLUND GUNNAR
分类号 C07D215/56;A61K31/47;A61K31/4704;A61P1/00;A61P3/10;A61P9/10;A61P11/00;A61P11/06;A61P17/06;A61P25/00;A61P25/28;A61P29/00;A61P37/00;A61P43/00;C07D215/22;C07D491/056 主分类号 C07D215/56
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