发明名称 |
ErbB-2 RECEPTOR TARGETING PEPTIDE |
摘要 |
The ErbB-2 receptor, a member of the tyrosine kinase type 1 family of receptors, has been implicated in many human malignancies. Bacteriophage display technology was employed to identify peptides that bound to the extracellular domain of human ErbB-2. The peptide KCCYSL, most frequently occurring in the affinity selected population, was chemically synthesized and characterized for its binding activities to the recombinant extracellular domain of ErbB-2. The synthetic peptide exhibits high specificity to ErbB-2 as well as to ErbB-1, another member of ErbB family. Thus, this peptide can be employed in cancer imaging or therapeutic agent targeting to malignant cells ErbB-2 receptor. |
申请公布号 |
WO2004005320(A3) |
申请公布日期 |
2005.12.29 |
申请号 |
WO2003US21150 |
申请日期 |
2003.07.03 |
申请人 |
THE CURATORS OF THE UNIVERSITY OF MISSOURI;QUINN, THOMAS, P.;KARASSEVA, NATALIA G. |
发明人 |
QUINN, THOMAS, P.;KARASSEVA, NATALIA G. |
分类号 |
A61K49/00;A61K51/00;G01N33/574;G01N33/74 |
主分类号 |
A61K49/00 |
代理机构 |
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