发明名称 |
FIBROBLAST GROWTH FACTOR RECEPTOR-1 INHIBITORS AND METHODS OF TREATMENT THEREOF |
摘要 |
The present invention is directed to an antibody or fragments thereof that are specific for a fibroblast growth factor receptor (FGFR)-1(IIIb), FGFR-1(IIIc), and/or FGFR-4. Also, provided herein, are vectors and host cells comprising the nucleic acids encoding those antibodies. The present invention further provides methods of antagonizing FGFR-1 or FGFR-4 as a treatment for obesity, diabetes, or a condition related thereto, and methods of reducing food intake. |
申请公布号 |
WO2005037235(A3) |
申请公布日期 |
2005.12.22 |
申请号 |
WO2004US34970 |
申请日期 |
2004.10.18 |
申请人 |
IMCLONE SYSTEMS INCORPORATED;SUN, HAIJUN;SHEN, JUQUN;TONRA, JAMES, R. |
发明人 |
SUN, HAIJUN;SHEN, JUQUN;TONRA, JAMES, R. |
分类号 |
A61K;A61K39/395;C07K16/28 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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