发明名称 |
COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF |
摘要 |
The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., DF508 CFTR, G551D-CFTR, G1349D-CFTR, or D1152H-CFTR, that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more phenylglycine-containing compounds or sulfonamide-containing compounds of the invention, or an analog or derivative thereof. |
申请公布号 |
WO2005120497(A2) |
申请公布日期 |
2005.12.22 |
申请号 |
WO2005US19346 |
申请日期 |
2005.06.02 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;VERKMAN, ALAN;GUY, R. KIPLIN;PEDEMONTE, NICOLETTA;GALIETTA, LUIS J.V. |
发明人 |
VERKMAN, ALAN;GUY, R. KIPLIN;PEDEMONTE, NICOLETTA;GALIETTA, LUIS J.V. |
分类号 |
A61K31/405 |
主分类号 |
A61K31/405 |
代理机构 |
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代理人 |
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