发明名称 |
LIPID ENCAPSULATED INTERFERING RNA |
摘要 |
The present invention is directed to lipid-based formulations for delivering, e.g., introducing, nucleic acid-lipid particles to a cell, and assays for optimizing the delivery efficiency of such lipid-based formulations. The nucleic acid-lipid particles comprise an interference RNA molecule, a cationic lipid with alkyl side chains from about 10 to about 20 carbon atoms having more than a single site of unsaturation, a noncationic lipid and a conjugated lipid that inhibits aggregation of the particle such as a polyethyleneglycol (PEG)-lipid conjugate or a polyamide (ATTA)-conjugate). |
申请公布号 |
WO2005121348(A1) |
申请公布日期 |
2005.12.22 |
申请号 |
WO2005CA00886 |
申请日期 |
2005.06.07 |
申请人 |
PROTIVA BIOTHERAPEUTICS, INC.;MACLACHLAN, IAN;PALMER, LORNE R.;HEYES, JAMES |
发明人 |
MACLACHLAN, IAN;PALMER, LORNE R.;HEYES, JAMES |
分类号 |
A61K9/127;A61K31/7105;A61K48/00;C12N15/11;C12N15/88 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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