| 摘要 |
A compound represented by the following general formula (I), its salt, its solvate or its N-oxide or prodrugs thereof: (I) wherein R1 and R2 represent each an optionally substituted cyclic group, etc.; W is a spacer having from 1 to 6 carbon atoms in its main chain; X represents -O-, etc.; A represents an optionally substituted cyclic group; Y is a spacer having from 1 to 6 carbon atoms in its main chain, etc.; and Z represents an acidic group. Because of having an activity of controlling peroxisome proliferator- activated receptors, the compounds are useful as preventives/remedies for metabolic errors such as hypercholesteremia and hyperlipoproteinemia, hyperlipemia, arteriosclerosis, hypertension, circulatory diseases, hyperphagia, ischemic heart diseases and so on, HDL cholesterol-elevating agents, LDL cholesterol and/or VLDL cholesterol-lowering agents, and drugs for relieving risk factors of diabetes and metabolic syndrome.
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